Systemic-onset JIA is most commonly associated with:

Systemic-onset JIA is most commonly associated with:

• A. Single joint involvement
• B. High, daily intermittent spiking fevers & rash
• C. Positive RF factor
• D. Painless joint involvement

Answer: (B)

Systemic-onset JIA is defined by prominent systemic inflammatory features that often precede or accompany arthritis. The hallmark is daily, high-fever spikes that come and go, frequently with a salmon-colored, transient rash that appears with the fever. This fever-rash pattern, along with possible hepatosplenomegaly, lymphadenopathy, and serositis, distinguishes this subtype from others where joint involvement is the primary or sole feature. Single joint involvement fits more with oligoarticular or early JIA subtypes, not the systemic form. Positive RF is characteristic of the RF-positive polyarticular form, not systemic-onset disease. Painless joint involvement is not typical for systemic-onset JIA, which often presents with inflammatory joint swelling and systemic symptoms.

Systemic-onset JIA is defined by prominent systemic inflammatory features that often precede or accompany arthritis. The hallmark is daily, high-fever spikes that come and go, frequently with a salmon-colored, transient rash that appears with the fever. This fever-rash pattern, along with possible hepatosplenomegaly, lymphadenopathy, and serositis, distinguishes this subtype from others where joint involvement is the primary or sole feature.

Single joint involvement fits more with oligoarticular or early JIA subtypes, not the systemic form. Positive RF is characteristic of the RF-positive polyarticular form, not systemic-onset disease. Painless joint involvement is not typical for systemic-onset JIA, which often presents with inflammatory joint swelling and systemic symptoms.