Which finding is most consistent with Edwards syndrome in a newborn?

Which finding is most consistent with Edwards syndrome in a newborn?

• A. Macroorchidism
• B. Hypotonia
• C. Brushfield spots
• D. Rocker-bottom feet

Answer: (D)

Edwards syndrome (trisomy 18) presents with multiple congenital anomalies, and rocker-bottom feet are a classic, highly characteristic finding in newborns. This specific foot deformity helps distinguish Edwards from other conditions. Macroorchidism is seen with other syndromes (like Fragile X or certain gonadal disorders), brushfield spots are associated with Down syndrome (trisomy 21), and hypotonia is common in many neonatal conditions but is not as distinguishing. Thus, rocker-bottom feet best fits Edwards syndrome.

Edwards syndrome (trisomy 18) presents with multiple congenital anomalies, and rocker-bottom feet are a classic, highly characteristic finding in newborns. This specific foot deformity helps distinguish Edwards from other conditions. Macroorchidism is seen with other syndromes (like Fragile X or certain gonadal disorders), brushfield spots are associated with Down syndrome (trisomy 21), and hypotonia is common in many neonatal conditions but is not as distinguishing. Thus, rocker-bottom feet best fits Edwards syndrome.