Which immunoglobulin level is reported as normal in Wiskott-Aldrich syndrome according to the provided material?

Which immunoglobulin level is reported as normal in Wiskott-Aldrich syndrome according to the provided material?

• A. IgA-decreased
• B. IgG-normal
• C. IgM-increased
• D. IgG-decreased

Answer: (B)

In Wiskott-Aldrich syndrome, the immunoglobulin pattern typically shows a low IgM with higher IgA and IgE, while IgG levels are usually normal or variable. So IgG being normal fits the common profile, because IgG isn’t consistently decreased or elevated in this condition. The other patterns don’t align with the usual WAS pattern: IgA is usually increased, not decreased; IgM is typically decreased, not increased; and IgG is not characteristically reduced. This reflects the underlying immune dysregulation in WAS, where initial IgM responses are impaired and other isotypes can be upregulated or remain stable.

In Wiskott-Aldrich syndrome, the immunoglobulin pattern typically shows a low IgM with higher IgA and IgE, while IgG levels are usually normal or variable. So IgG being normal fits the common profile, because IgG isn’t consistently decreased or elevated in this condition. The other patterns don’t align with the usual WAS pattern: IgA is usually increased, not decreased; IgM is typically decreased, not increased; and IgG is not characteristically reduced. This reflects the underlying immune dysregulation in WAS, where initial IgM responses are impaired and other isotypes can be upregulated or remain stable.